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KMID : 0617219990100010003
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Duksung Bulletin Phamaceutical Sciences
1999 Volume.10 No. 1 p.3 ~ p.8
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Selective Bromination of Aromatic Nucleus
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Abstract
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2-Bromo monosubstituent of 3,4-methylenedioxybenzoic acids was obtained from selective bromination in the presence of bromine in glacial acetic acid. Reaction was sucessfully proceeded through stirring of glacial acetic acid after dropwise over 4 h 100mol％ of bromine and acetic acid at room temperature for 18 h. 2-Position rather than 6-position of aromatic nucleus was substituted first during bromination, and thereafter 2,6-disubstituted analogue followed even though steric hindrance.
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